About our company

America Diagnosis, Inc. Doing Business As (DBA) AprexBio, in San Diego, California, offers reliable biology research reagents, high quality protein expression contract services, from gene design, DNA cloning to target protein expression and purification.

Since 2014, ISO9001:2008 quality management system has been executed in house, ensuring AprexBio products’ reproducibility.

AprexBio has developed an unique in-house inducible gene expression module, designated APXexpTM, this module can be adapted to both prokaryotic (gram-positive and negative bacteria) and eukaryotic protein expression system (Drosophila S2 cells and mammalian cell lines), induce the target gene transcription at a fully controllable rate, giving necessary time for de novo proteins to fold at right conformation. APXexpTM has been proved to express high yield of difficult proteins by traditional IPTG protein expression systems, such as Granenzyme B and HE4.

In Bacteria, APXexpTM vectors have a broad host range origin, which can initiate the replication in majority of the gram-negative and gram-positive bacteria, offers a great opportunity to tackle some difficult proteins for E. coli protein expression system. We have successfully expressed and purified his-tag GFP proteins from BL21(DE3), Pseudomans aeruginosa, and Bacillus subtilis at desirable yield.

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